Aquaporin-4 IgG autoimmune syndrome and immunoreactivity associated with thyroid cancer

Aquaporin-4 IgG autoimmune syndrome and immunoreactivity associated with thyroid cancer

Tumor cells can express so-called onconeural antigens, which are normally restricted to mature neurons and glial cells in the CNS. The detection of neuralreactive immunoglobulin G (IgG) aids the diagnosis of paraneoplastic neurologic syndromes (PNS); however, the diagnostic utility and potential pathogenicity of autoantibodies vary between neurologic diseases. By contrast, anti-aquaporin-4 (AQP...

High-titer Anti-aquaporin-4-IgG-associated Myelitis in Rhupus Syndrome.

An autoimmune channelopathy associated with cancer: Lambert-Eaton myasthenic syndrome.

The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that is often associated with lung cancer which shares a common antigenic protein with the motor nerve terminal. The myasthenic weakness is caused by an antibody-induced reduction in the release of acetylcholine from the nerve terminal. This study was undertaken to determine the target of LEMS antibodies and specify the volta...

prevalence of autoantibodies to thyroid peroxidase and autoimmune thyroid disease in girls with turner’s syndrome

patients with turner’s syndrome (ts) are at an increased risk of developing autoimmune thyroid disease (atd). the aim of this study was to determine the frequency of anti-thyroid peroxidase (anti-tpo) antibodies and atd in children and adolescent girls with ts. it also assessed the influence of karyotype on the development of thyroid disease. sixty eight patients with ts were compared with 68 a...

Aquaporin-4–positive myelitis associated with Sjögren syndrome and colonic adenocarcinoma

Neuromyelitis optica (NMO) is an inflammatory disorder of the CNS with prominent involvement of the optic nerve and the spinal cord. An autoantibody against aquaporin-4 (AQP4), a water channel abundant on astrocytic foot processes, is the biomarker of the disease. The term neuromyelitis optica spectrum disorders (NMOSD) includes AQP4-IgG-positive syndromes that may only partially fulfill contem...